• 29 NOV 18
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    Sirolimus & Facial Angiofibromas

    Sirolimus & Facial Angiofibromas

    Angiofibromas are overgrowths of skin( skin lesions/growth). They are usually scattered on the nose and cheeks. Sometimes they can be present on the forehead, eyelids, and chin. They can be the same colour as the person’s natural skin colour, but can also appear as a different colour (such as pink, red or brown). In childhood, angiofibromas may appear as a redness of the cheeks. The redness is due to an increase in the blood vessels of the skin. Angiofibromas may appear as early as the first year of life, but usually begin to appear when the child is about five years old. Angiofibromas may increase in number and become more noticeable at puberty. As a person gets older, angiofibromas may become raised. This is due to the growth of fibrous tissue (similar to that found in a scar) in the affected area of the skin. They are associated with flushing of the face, which is worse when the affected person is hot or emotional.

    The use of topical Sirolimus ointment appears to be relatively side-effect free. Their use has been associated with dramatic improvement of skin lesions. Topical preparations (which are applied to the skin) may also be a cost-effective option for the management of facial angiofibromas when compared to surgical options that may require general anaesthesic.

     

    Reference: file:///C:/Users/user/Downloads/TSA+Factsheets+2017+A5+-+TSC+and+Facial+Angiofibromas.pdf

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